![]() However, not all patients produce IgM antibodies in the acute phase of infection besides, IgM antibodies may also be detectable in cases of recurrent or persistent infection. In addition, detection of IgM antibodies against HSV is important to confirm acute primary infection. In the acute stage of infection direct detection of the virus from the vesicles content via PCR is indicated. The virus is often reactivated, leading to recurrent symptoms. Herpes simplex virus infects the neurons of the dorsal root ganglia, where it causes lifelong latent infection. Severe manifestations, such as an HSV-associated encephalitis or herpes corneae are rare. In the acute stage of herpes infection skin lesions with characteristic blisters (“cold sore”) occur by HSV-1 or genitalia sores which associated with STD infections. Positive IgM anti-herpes antibodies Virus 1 and 2 means the body just started the immunity response against the herpes virus, while beginning of the virus infection may be occurred several weeks ago. Positive IgG antibodies against Virus herpes 1 means the body is immune to this virus or the immunity still build up, the same for IgG antiherpes antibodies means an old infection that the body has built defense against. while this waiting period the Herpes antibodies test is not useful to detect herpes infection, instead take a PCR test from sores directly and virus culture from open blisters and fluids as CSF or urine. The story behind antibodies tests is that: when a virus invade the body, our immune system take the responsibility to kill and eliminate this virus from all body tissues, the first immunity weapon is IgM antibodies which take the first impressions about virus and send them to the core immune system, which in turn continue to build suitable antibodies that fit to all virus aspects, finally the immune system understand the integrity of the invading virus and send the larger IgG antibodies, so that when we see IgG positive test we know that the body has fully eliminated the virus, and IgM positive test means the beginning of immunity war against virus, of course the beginning of virus invasion could precedes the body response by 2 – 6 weeks and up to 3 months, which called the dormant period, window period, or virus outbreak, That is why can you have herpes and test negative. Serological Herpes testing, is it reliable? PCR test results are ready in 1 to 3 days. Results for a rapid herpes virus culture may take 2 to 3 days, anti-herpes antibody detection test results are ready in a day. How long does it take to get herpes test results? Perinatal infection of the newborn can lead to a severe generalized neonatal herpes infection which has the medical term Herpes neonatorum. Thus it is always recommended to determine a woman’s HSV status during pregnancy, including discrimination of HSV-1 und HSV-2, to estimate the newborn’s risk for perinatal infection. In general, primary HSV-1 infection occurs during childhood, while HSV-2 infection is usually acquired sexually in early adulthood. The infection only spreads when a susceptible person comes into close contact with tissue or body fluids containing the virus. In general, HSV-1 infection rates are markedly higher compared to HSV-2 Both, HSV-1 and HSV-2 infect epithelial cells of the mucous membranes, HSV-1 localizes preferentially in the orofacial region (Herpes 1 called Herpes labialis) and HSV-2 in genital and anal areas (Herpes 2 called Herpes genitalis). In the latent stage, the production of infectious virus particles is inhibited but periodic reactivation and successive cycles of virus replication lead to reproduction and spreading to further susceptible persons. Like other herpesviruses, HSV-1 and HSV-2 follow a productive lytic infection and establish a latent lifelong infection in the host. All herpesviruses are composed of relatively large DNA genomes. Herpes simplex virus type 1 and type 2 (HSV-1 and HSV-2) are pathogenic to humans and belong to the herpesvirus family. Herpes infection is one of sexually transmitted diseases which include AIDS and chlamydia for example. Herpes are group of 8 virus types, only two of them cause disease, one of them is Herpes simples virus (medical term is HHV 1,2 or HSV 1,2) What Herpes test is earlier and most accurate for the recent virus infection, why negative results and outbreak, read carefully and understand herpes test results.
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